Cross County is a county located in the U.S. state of Arkansas. As of the 2000 census, the population was 19,526. The county seat is Wynne. Cross County is

Arkansas's 53rd county, formed on 15 November 1862 and named for Confederate Colonel David C. Cross, a political leader in the area. Cross County was formed November 15,1862 from parts of Crittenden, Poinsett, and St. Francis counties. It was named for Col. David Cross, a Confederate officer.

Cross County has rich, flat delta farmland in the east and west and rolling hills in the center. Agriculture and related enterprises are major to the county with rice bringing in more than half the county's revenues. Soybeans and cotton are other main crops while peaches and other fruit crops are predominate on Crowly's Ridge. The Wittsburg Natural Area preserves a good sample of Crowley's Ridge covered with beech and sugar maple trees, spring wildflowers.